In 1999, Time
magazine stated that penicillin “was a discovery that would change the
course of history.” It was the first of many antibiotics, or substances
derived from microbes (fungi or bacteria) that kill or control the growth of
other microbes. The earliest accounts of the healing properties of moldy bread
appeared from ancient Egypt some 3,500 years ago in the Ebers Papyrus.
In 1877, Louis Pasteur demonstrated that one microbe could be used to combat
another and termed this antibiosis. He inoculated animals with a mixture of the
anthrax bacillus and another common bacteria, which protected them against the
deadly anthrax infection. Pasteur postulated that microbes released materials
that might be used therapeutically, a prediction validated six decades later.
Alexander Fleming served in a
battlefield hospital on the Western Front in France during World War I and
observed that more soldiers were dying from antiseptics used to treat infected
wounds than from the infected wounds. After the war, the Scottish-born Fleming
resumed his bacteriological research at St. Mary’s Hospital Medical School in
London. By 1928, when he turned his attention to the staphylococcus bacterium,
he had gained the reputation as a well-respected scientist but one who did not
maintain a neat laboratory.
After returning from a
month-long family vacation in September 1928, he found that one of his culture
dishes was contaminated and that there was no growth of staph colonies
surrounding the fungal-contaminated growth. He astutely recognized what
countless other scientists had overlooked: the fungus may have released an
antibacterial substance. He grew a pure culture of the fungus, Penicillium
notatum, and found that it selectively killed many, but not all, bacteria. He
named this substance penicillin and in 1929 authored a paper that described its
effects. Minimal interest was shown in his work until war clouds hung ominously
over Europe in 1940, when penicillin’s potential was recognized and it was
isolated and purified. Some sources estimate that penicillin saved the lives of
millions of soldiers who would have died from infections of battle wounds.
Accordingly, Fleming was a co-recipient of the 1945 Nobel Prize.
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