Jan 21, 2016

The Placenta's Tale: From Ancient Mysteries to Modern Science

The fascination with the enigmatic placenta, its historical significance, and intricate functions stretches from ancient times to the present day. In Egypt, a sculpture venerates the royal placenta, linked by an umbilical cord, and hails it as the Pharaoh's "soul" or "secret helper," believing the kingdom's prosperity rested on the sovereign's well-being and preservation of his soul. The Hebrew Bible terms it the "Bundle of Life" and "External Soul." The placenta, its name derived from the Greek "flat cake," captivated the curiosity of luminaries like Aristotle and Galen, the preeminent scholars of antiquity. Aristotle, around 340 BCE, commenced the examination and nomenclature of fetal membranes but faced challenges due to species variations and his use of animal subjects, leading to some erroneous conclusions that endured for centuries.

Around 1510, Leonardo da Vinci channeled his genius into anatomical depictions, including those of the fetus, portraying the uterus with its blood vessels, fetal membranes, and umbilical cord. He posited that fetal blood vessels remained distinct from the mother's, a longstanding inquiry from ancient times to the eighteenth century. In his 1628 medical masterpiece "De Motu Cordis," William Harvey laid the groundwork for our contemporary comprehension of circulatory system and heart physiology.

In 1651, Harvey expanded his inquiries to scrutinize fetal circulation and its interaction with the mother's. He posed a fundamental question: How does the fetus endure and respire in the womb for months yet succumb shortly after birth if unable to breathe? Recognizing the separate circulatory systems of mother and fetus, he proposed that the amniotic sac's fluid nourished and oxygenated the fetus. We now understand that from the fourth week of development until birth, the placental circulation facilitates the exchange of nutrients, respiratory gases, and waste materials between the embryo, fetus (post the ninth week), and the mother.


In this illustration from Dr. Paul Labarthe's "Usual Medicine Dictionary" of 1885, we witness the imminent birth of a fetus.

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